Tight Junction

Preferred Label : Tight Junction;

NCIt synonyms : Occluding Junction; Zonula Occludens;

NCIt definition : Found near the apical surface of cells in simple epithelia. Forms a sealing gasket around the cell by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence. Prevents fluid moving through the intercellular gap and the lateral diffusion of intrinsic membrane proteins between apical and basolateral domains of the plasma membrane as well as occludes the movement of solute molecules between cells. Various proteins components of this junction have been identified, but how they are linked to form the ultrastructure of the junction is not known.;

Details

Origin ID

C13333;

UMLS CUI

C0242358;

Anatomic structure is physical part of
- Cell [NCIt concept]
- Cell Surface [NCIt concept]
- Epithelium [NCIt concept]
Associated anatomy of gene products
- Angiomotin [NCIt concept]
- Cingulin-Like Protein 1 [NCIt concept]
- Claudin-1 [NCIt concept]
- Claudin-18 [NCIt concept]
- Claudin-18 Isoform A2 [NCIt concept]
- Claudin-6 [NCIt concept]
- Claudin-7 [NCIt concept]
- Coxsackievirus and Adenovirus Receptor [NCIt concept]
- Junctional Adhesion Molecule A [NCIt concept]
- MARVEL Domain-Containing Protein 2 [NCIt concept]
- Membrane-Associated Guanylate Kinase, WW and PDZ Domain-Containing Protein 1 [NCIt concept]
- Membrane-Associated Guanylate Kinase, WW and PDZ Domain-Containing Protein 3 [NCIt concept]
- Partitioning Defective 6 Homolog Alpha [NCIt concept]
- Protein ECT2 [NCIt concept]
- Protein PALS1 [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Striatin [NCIt concept]
- Tight Junction Protein ZO-1 [NCIt concept]
Currated CISMeF NLP mapping
- Occluding cell junction [FMA entity]
- bicellular tight junction [GO term]
- tight junction [GO term]
- tight junction [SNOMED Notion]
- tight junctions [MeSH Descriptor]
- tight junctions [MeSH concept]
False automatic mappings
- Tight junction (cell structure) [SNOMED CT concept]
Semantic type(s)
- Body Space or Junction [UMLS semantic type]
UMLS correspondences (same concept)
- Occluding cell junction [FMA entity]
- Tight junction (cell structure) [SNOMED CT concept]
- bicellular tight junction [GO term]
- tight junction [GO term]
- tight junction [SNOMED Notion]
- tight junctions [MeSH concept]
- tight junctions [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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