Rap Guanine Nucleotide Exchange Factor 2

Preferred Label : Rap Guanine Nucleotide Exchange Factor 2;

NCIt synonyms : RA-GEF-1; CNrasGEF; PDZ-GEF1; Ras/Rap1-Associating GEF-1; Neural RAP Guanine Nucleotide Exchange Protein; Cyclic Nucleotide Ras GEF; Ras-Associating Guanine Nucleotide Exchange Factor; nRap GEP; RAPGEF2; PDZ Domain-Containing Guanine Nucleotide Exchange Factor 1;

NCIt definition : Rap guanine nucleotide exchange factor 2 (1499 aa, 167 kDa) is encoded by the human RAPGEF2 gene. This protein is involved in regulation of signaling downstream of ligand-activated beta-1 adrenergic receptor.;

Details

Origin ID

C185577;

UMLS CUI

C0910576;

OMIM relation
- Rap guanine nucleotide exchange factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RAPGEF2 protein, human [MeSH Supplementary Concept]
- RAPGEF2 protein, human [MeSH concept]
gene_encodes_gene_product
- RAPGEF2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Endocrine Cell [NCIt concept]
- Late Endosome [NCIt concept]
- Neuron [NCIt concept]
- Plasma Membrane [NCIt concept]
- Tight Junction [NCIt concept]
gene_product_has_structural_domain_or_motif
- PDZ Domain [NCIt concept]
gene_product_is_element_in_pathway
- MAPK Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Neural Development [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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