" /> Partitioning Defective 6 Homolog Alpha - CISMeF





Preferred Label : Partitioning Defective 6 Homolog Alpha;

NCIt synonyms : PAR-6A; TIP-40; Tax-Interaction Protein 40 Par-6 (Partitioning Defective 6, C.elegans) Homolog Alpha; PAR6C; Partitioning Defective-6 Homolog Alpha; PARD6A; PAR-6; PAR-6 Alpha; Partitioning-Defective Protein 6; Tax Interaction Protein 40; Par-6 Partitioning Defective 6 Homolog Alpha; Tax Interaction Protein-40;

NCIt definition : Partitioning defective 6 homolog alpha (346 aa, 37 kDa) is encoded by the human PARD6A gene. This protein is involved in tight junction formation, asymetrical cell division, and cell polarization processes as an adaptor signaling protein.;

NCIt note : The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Formation of this complex may also inhibit the interaction of PARD3 with F11R/JAM1, which prevents tight junction assembly. (UniProt);

NCI Metathesaurus CUI : CL448580;

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09/07/2025


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