Partitioning Defective 6 Homolog Alpha

Preferred Label : Partitioning Defective 6 Homolog Alpha;

NCIt synonyms : PAR-6A; TIP-40; Tax-Interaction Protein 40 Par-6 (Partitioning Defective 6, C.elegans) Homolog Alpha; PAR6C; Partitioning Defective-6 Homolog Alpha; PARD6A; PAR-6; PAR-6 Alpha; Partitioning-Defective Protein 6; Tax Interaction Protein 40; Par-6 Partitioning Defective 6 Homolog Alpha; Tax Interaction Protein-40;

NCIt definition : Partitioning defective 6 homolog alpha (346 aa, 37 kDa) is encoded by the human PARD6A gene. This protein is involved in tight junction formation, asymetrical cell division, and cell polarization processes as an adaptor signaling protein.;

NCIt note : The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Formation of this complex may also inhibit the interaction of PARD3 with F11R/JAM1, which prevents tight junction assembly. (UniProt);

NCI Metathesaurus CUI : CL448580;

Details

Origin ID

C30122;

UMLS CUI

C1335190;

OMIM relation
- Par6 family cell polarity regulator alpha [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- Par6 family cell polarity regulator alpha [OMIM gene]
- par-6 family cell polarity regulator alpha [HGNC gene]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- PARD6A Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Tight Junction [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- PDZ Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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