Rho Guanine Nucleotide Exchange Factor 2

Preferred Label : Rho Guanine Nucleotide Exchange Factor 2;

NCIt synonyms : Guanine Nucleotide Exchange Factor H1; GEF-H1; Proliferating Cell Nucleolar Antigen p40; Microtubule-Regulated Rho-GEF; ARHGEF2;

NCIt definition : Rho guanine nucleotide exchange factor 2 (986 aa, 112 kDa) is encoded by the human ARHGEF2 gene. This protein is involved in the regulation of both guanine nucleotide exchange and signal transduction.;

Details

Origin ID

C101782;

UMLS CUI

C3539612;

OMIM relation
- Rho guanine nucleotide exchange factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ARHGEF2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ARHGEF2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Microtubule [NCIt concept]
- Tight Junction [NCIt concept]
gene_product_has_chemical_classification
- Microtubule Associated Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Phosphoinositide Pathway [NCIt concept]
- Reelin Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Negative Regulation of Microtubule Depolymerization [NCIt concept]
- Phospholipid Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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