PH Domain - CISMeF

Preferred Label : PH Domain;

NCIt synonyms : Pleckstrin-Homology Domain; Pleckstrin Homology Domain;

NCIt definition : Pleckstrin-homology (PH) domains are protein modules of approximately 120 amino acids found in a wide variety of signaling proteins in organisms ranging from yeast to humans. Some PH domains bind with high affinity (low mM or nM Kd) to specific phosphoinositides such as phosphatidyl-inositol (PI) -4,5-bisphosphate, PI-3,4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/lambda subunits of heterotrimeric G proteins.;

Details

Origin ID

C14077;

UMLS CUI

C1518792;

Automatic exact mappings (from CISMeF team)
- Pleckstrin Homology Domains [MeSH Descriptor]
- Pleckstrin Homology Domains [MeSH concept]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- Pleckstrin Homology Domains [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- A-Kinase Anchor Protein 13 [NCIt concept]
- Anillin [NCIt concept]
- Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain-Containing 1 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 1 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 2 [NCIt concept]
- Calcium-Dependent Secretion Activator 2 [NCIt concept]
- Ceramide Transfer Protein [NCIt concept]
- Citron Rho-Interacting Kinase [NCIt concept]
- Connector Enhancer of Kinase Suppressor of Ras 1 [NCIt concept]
- Cytoplasmic Tyrosine-Protein Kinase BMX [NCIt concept]
- Docking Protein 1 [NCIt concept]
- Dynamin-1 [NCIt concept]
- Dynamin-2 [NCIt concept]
- Engulfment and Cell Motility Protein 1 [NCIt concept]
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8 [NCIt concept]
- FYVE, RhoGEF and PH Domain-Containing Protein 1 [NCIt concept]
- FYVE, RhoGEF and PH Domain-Containing Protein 4 [NCIt concept]
- FYVE, RhoGEF and PH Domain-Containing Protein 5 [NCIt concept]
- Fermitin Family Homolog 2 [NCIt concept]
- Fermitin Family Homolog 3 [NCIt concept]
- GRB2-Associated-Binding Protein 1 [NCIt concept]
- GRB2-Associated-Binding Protein 2 [NCIt concept]
- Growth Factor Receptor-Bound Protein 10 [NCIt concept]
- Growth Factor Receptor-Bound Protein 14 [NCIt concept]
- Growth Factor Receptor-Bound Protein 7 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV3 [NCIt concept]
- IQ Motif and SEC7 Domain-Containing Protein 1 [NCIt concept]
- IQ Motif and SEC7 Domain-Containing Protein 2 [NCIt concept]
- Insulin Receptor Substrate 4 [NCIt concept]
- Intersectin-1 [NCIt concept]
- Kalirin [NCIt concept]
- Lipopolysaccharide-Responsive and Beige-Like Anchor Protein [NCIt concept]
- Low Density Lipoprotein Receptor Adapter Protein 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 8 [NCIt concept]
- Oligophrenin-1 [NCIt concept]
- Oncogene TIM Protein [NCIt concept]
- Oxysterol-Binding Protein 2 [NCIt concept]
- Oxysterol-Binding Protein-Related Protein 10 [NCIt concept]
- PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein [NCIt concept]
- Pleckstrin Homology Domain-Containing Family A Member 2 [NCIt concept]
- Pleckstrin Homology Domain-Containing Family G Member 5 [NCIt concept]
- Pleckstrin Homology-Like Domain Family A Member 2 [NCIt concept]
- Pleckstrin Homology-Like Domain Family B Member 3 [NCIt concept]
- Protein ECT2 [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Ras GTPase-Activating Protein 1 [NCIt concept]
- Ras GTPase-Activating Protein 2 [NCIt concept]
- Ras GTPase-Activating Protein nGAP [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 1 [NCIt concept]
- Ras/Rap GTPase-Activating Protein SynGAP [NCIt concept]
- RasGAP-Activating-Like Protein 1 [NCIt concept]
- Rho GTPase-Activating Protein 22 [NCIt concept]
- Rho GTPase-Activating Protein 24 [NCIt concept]
- Rho GTPase-Activating Protein 26 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 12 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 28 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 5 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 7 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor TIAM2 [NCIt concept]
- SH2B Adapter Protein 1 [NCIt concept]
- SH2B Adapter Protein 2 [NCIt concept]
- SH2B Adapter Protein 3 [NCIt concept]
- SH3 Domain-Binding Protein 2 [NCIt concept]
- Serine/Threonine-Protein Kinase D1 [NCIt concept]
- Serine/Threonine-Protein Kinase D2 [NCIt concept]
- Serine/Threonine-Protein Kinase D3 [NCIt concept]
- Signal-Transducing Adaptor Protein 1 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Src Kinase-Associated Phosphoprotein 1 [NCIt concept]
- Src Kinase-Associated Phosphoprotein 2 [NCIt concept]
- T-Lymphoma Invasion and Metastasis-Inducing Protein 1 [NCIt concept]
- TBC1 Domain Family Member 2B [NCIt concept]
- Triple Functional Domain Protein [NCIt concept]
- Tyrosine-Protein Kinase BTK [NCIt concept]
- Tyrosine-Protein Kinase TEC [NCIt concept]

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