Rho Guanine Nucleotide Exchange Factor 1

Preferred Label : Rho Guanine Nucleotide Exchange Factor 1;

NCIt synonyms : Rho GEF 1; ARHGEF1; Sub1.5; Lsc Homolog; 115 kDa Guanine Nucleotide Exchange Factor; p115-RHOGEF; p115RhoGEF; Rho Guanine Nucleotide Exchange Factor-1;

NCIt definition : Rho guanine nucleotide exchange factor 1 (912 aa, 102 kDa) is encoded by the human ARHGEF1 gene. This protein plays a role in the regulation of transforming protein RhoA-dependent signaling.;

Details

Origin ID

C20942;

UMLS CUI

C3711779;

Automatic exact mappings (from CISMeF team)
- Rho guanine nucleotide exchange factor 1 [OMIM gene]
- Rho guanine nucleotide exchange factor 1 [HGNC gene]
- rho guanine nucleotide exchange factor p115 [MeSH concept]
- rho guanine nucleotide exchange factors [MeSH Descriptor]
OMIM relation
- Rho guanine nucleotide exchange factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ARHGEF1 protein, human [MeSH Supplementary Concept]
- ARHGEF1 protein, human [MeSH concept]
- rho guanine nucleotide exchange factor p115 [MeSH concept]
gene_encodes_gene_product
- ARHGEF1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
- RGS Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Myosin Phosphatase Pathway [NCIt concept]
- Rho Cell Motility Signaling Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Thrombin/Protease-Activated Receptor Signaling Pathway [NCIt concept]
- Thromboxane A2 Receptor Family Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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