Myotubularin-Related Protein 5

Preferred Label : Myotubularin-Related Protein 5;

NCIt synonyms : SET Binding Factor 1; SBF1; Inactive Phosphatidylinositol 3-Phosphatase 5; SET-Binding Factor 1; MTMR5;

NCIt definition : Myotubularin-related protein 5 (1868 aa, 208 kDa) is encoded by the human SBF1 gene. This protein is involved in the regulation of myotubularin-related protein 2 (MTMR2)-mediated phosphoinositol phosphatase activity and guanine nucleotide exchange activity for Rab family proteins.;

NCIt note : Although myotubularin-related protein 5 belongs to the non-receptor phosphatase myotubularin subfamily, it lacks the conserved active site cysteine residue at position 1422 in the presumptive catalytic loop and does not have phosphatase activity. (UniProt);

Details

Origin ID

C204992;

OMIM relation
- Set-binding factor 1 [OMIM gene]
gene_encodes_gene_product
- SBF1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_structural_domain_or_motif
- PH Domain [NCIt concept]
- PTB Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Phospholipid Metabolism [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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