Preferred Label : PTB Domain;
NCIt synonyms : Phosphotyrosine Binding Domain; PID; Phosphotyrosine Interaction Domain; PTB; PID Domain;
NCIt definition : Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind
Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require
ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal
sequences are also required for high affinity binding and conferring specificity.
The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif
makes a turn, positioning the pY for recognition by basic residues. The PTB domains
of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide
motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB
domain can bind an unrelated peptide that forms a helical turn.;
Origin ID : C26118;
UMLS CUI : C1518827;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
