SHC-Transforming Protein 3

Preferred Label : SHC-Transforming Protein 3;

NCIt synonyms : NSHC; SHC3; SHCC; Neuronal SHC-Like Protein; SRC Homology 2 Domain Containing Transforming Protein C3; Neuronal-SHC Protein; Neuronal SHC; N-Shc; SH2 Domain Protein C3; Src Homology 2 Domain-Containing Transforming Protein C3; SHC Protein C; SHC Transforming Protein 3; SHC-Transforming Protein C; Protein Rai; Src Homology 2 Domain-Containing-Transforming Protein C3;

NCIt definition : SHC-transforming protein 3 (594 aa, 64 kDa) is encoded by the human SHC3 gene. This protein is involved in the mediation of growth factor receptor-dependent signaling pathways in neurons.;

NCIt note : SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB.;

Details

Origin ID

C29961;

UMLS CUI

C1312067;

OMIM relation
- Shc transforming protein 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SHC3 protein, human [MeSH concept]
- SHC3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- SHC3 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
- SH2 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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