Neurotrophin Signaling Pathway

Preferred Label : Neurotrophin Signaling Pathway;

Alternative definition : KEGG: Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and negative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.;

KEGG ID : hsa04722;

Details

Origin ID

C91443;

UMLS CUI

C2984256;

Automatic exact mappings (from CISMeF team)
- neurotrophin signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- neurotrophin signaling pathway [GO term]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- 14-3-3 Protein Epsilon [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Apoptosis Regulator BAX [NCIt concept]
- BDNF/NT-3 Growth Factors Receptor [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Beta-Nerve Growth Factor [NCIt concept]
- Brain-Derived Neurotrophic Factor [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Calmodulin [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Fibroblast Growth Factor Receptor Substrate 2 [NCIt concept]
- Forkhead Box Protein O3 [NCIt concept]
- GRB2-Associated-Binding Protein 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 1 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 3 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 4 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase-Like 2 [NCIt concept]
- MAP Kinase-Activated Protein Kinase 2 [NCIt concept]
- Megakaryocyte-Associated Tyrosine-Protein Kinase [NCIt concept]
- Melanoma-Associated Antigen D1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 5 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- NF-Kappa-B Inhibitor Epsilon [NCIt concept]
- NT-3 Growth Factor Receptor [NCIt concept]
- Neurotrophin-3 [NCIt concept]
- PR Domain Zinc Finger Protein 4 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Presenilin-1 [NCIt concept]
- Presenilin-2 [NCIt concept]
- Protein BEX3 [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAS-Related Protein Rap-1A [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Rho GDP-Dissociation Inhibitor 1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-3 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-5 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-6 [NCIt concept]
- SH2B Adapter Protein 2 [NCIt concept]
- SH2B Adapter Protein 3 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- SHC-Transforming Protein 3 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Sortilin [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 16 [NCIt concept]
- Tumor Protein p73 [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
- [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 1, Mitochondrial [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARHGDIA wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BDNF wt Allele [NCIt concept]
- BEX3 wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- FOXO3 wt Allele [NCIt concept]
- FRS2 wt Allele [NCIt concept]
- GAB1 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IRAK1 wt Allele [NCIt concept]
- IRAK2 wt Allele [NCIt concept]
- IRAK3 wt Allele [NCIt concept]
- IRAK4 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAGED1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K3 wt Allele [NCIt concept]
- MAP3K5 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK7 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MAPKAPK2 wt Allele [NCIt concept]
- MATK wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NFKBIB wt Allele [NCIt concept]
- NFKBIE wt Allele [NCIt concept]
- NGF wt Allele [NCIt concept]
- NGFR wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NTF3 wt Allele [NCIt concept]
- NTRK1 wt Allele [NCIt concept]
- NTRK2 wt Allele [NCIt concept]
- NTRK3 wt Allele [NCIt concept]
- PDK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PLCG2 wt Allele [NCIt concept]
- PRDM4 wt Allele [NCIt concept]
- PRKCD wt Allele [NCIt concept]
- PSEN1 wt Allele [NCIt concept]
- PSEN2 wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAP1A wt Allele [NCIt concept]
- RAPGEF1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RIPK2 wt Allele [NCIt concept]
- RPS6KA1 wt Allele [NCIt concept]
- RPS6KA2 wt Allele [NCIt concept]
- RPS6KA3 wt Allele [NCIt concept]
- RPS6KA5 wt Allele [NCIt concept]
- RPS6KA6 wt Allele [NCIt concept]
- SH2B1 wt Allele [NCIt concept]
- SH2B2 wt Allele [NCIt concept]
- SH2B3 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SHC3 wt Allele [NCIt concept]
- SORT1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- TP73 wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]
- YWHAE wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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