E3 Ubiquitin-Protein Ligase CBL-C

Preferred Label : E3 Ubiquitin-Protein Ligase CBL-C;

NCIt synonyms : SH3-Binding Protein CBL-C; SH3-Binding Protein CBL-3; RING Finger Protein 57; CBLC; Signal Transduction Protein CBL-C; EC 6.3.2.-, Formerly; EC 2.3.2.27;

NCIt definition : E3 ubiquitin-protein ligase CBL-C (474 aa, 52 kDa) is encoded by the human CBLC gene. This protein is involved in ubiquitination of tyrosine kinases, which promotes kinase degradation and modulates signaling pathways.;

NCIt note : E3 ubiquitin-protein ligase CBL-C substrates include epidermal growth factor receptor, poto-oncogene tyrosine-protein kinase Src and proto-oncogene tyrosine-protein kinase receptor Ret. (UniProt);

Details

Origin ID

C97441;

UMLS CUI

C0768360;

OMIM relation
- Cas-br-M murine ecotropic retroviral transforming sequence C [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CBLC protein, human [MeSH Supplementary Concept]
- CBLC protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CBLC Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction Inhibition [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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