Tyrosine-Protein Phosphatase Non-Receptor Type 22

Preferred Label : Tyrosine-Protein Phosphatase Non-Receptor Type 22;

NCIt synonyms : PTPN22; PEP; LyP; Hematopoietic Cell Protein-Tyrosine Phosphatase 70Z-PEP; Lymphoid Phosphatase; EC 3.1.3.48; PEST-Domain Phosphatase; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Non-Receptor Type 22 Protein Tyrosine Phosphatase;

NCIt definition : Tyrosine-protein phosphatase non-receptor type 22 (807 aa, 92 kDa) is encoded by the human PTPN22 gene. This protein is involved in both protein dephosphorylation and modulation of T-cell receptor signaling.;

Details

Origin ID

C26342;

UMLS CUI

C1335057;

Automatic exact mappings (from CISMeF team)
- Lymphomatoid papulosis [ORDO Disease]
- Lymphoproliferative syndrome, X-linked, 1 [OMIM Phenotype]
- Protein tyrosine phosphatase, nonreceptor-type, 22 [OMIM gene]
- SH2 domain containing 1A [ORDO Gene]
- hiv: prep and pep [MedlinePlus Topic]
- peptamen [MeSH Supplementary Concept]
- poly(1,2-ethylenepiperidine) N-oxide [MeSH Supplementary Concept]
- protein tyrosine phosphatase non-receptor type 22 [ORDO Gene]
- protein tyrosine phosphatase non-receptor type 22 [HGNC gene]
Currated CISMeF NLP mapping
- protein tyrosine phosphatase, Non-Receptor type 22 [MeSH Descriptor]
- protein tyrosine phosphatase, Non-Receptor type 22 [MeSH concept]
False automatic mappings
- Epilepsy, partial, with pericentral spikes [OMIM Phenotype]
OMIM relation
- Protein tyrosine phosphatase, nonreceptor-type, 22 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTPN22 protein, human [MeSH concept]
- PTPN22 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Non-Receptor Protein Tyrosine Phosphatase Gene [NCIt concept]
- PTPN22 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
- T-Lymphocyte [NCIt concept]
- Thymocyte [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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