Tyrosine-Protein Phosphatase Non-Receptor Type 6

Preferred Label : Tyrosine-Protein Phosphatase Non-Receptor Type 6;

NCIt synonyms : Protein Tyrosine Phosphatase SHP-1; Protein Tyrosine Phosphatase 1C; PTPN6; Hematopoietic Cell Protein Tyrosine Phosphatase; EC 3.1.3.48; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Hematopoietic Cell Protein-Tyrosine Phosphatase; PTP-1C; SH-PTP1; Protein-Tyrosine Phosphatase 1C; Non-Receptor Type 6 Protein Tyrosine Phosphatase; Hematopoietic Cell Phosphatase; Tyrosine Phosphatase SHP1; Protein-Tyrosine Phosphatase, Nonreceptor-Type, 6;

NCIt definition : Tyrosine-protein phosphatase non-receptor type 6 (595 aa, 66 kDa) is encoded by the human PTPN6 gene. This protein plays a role in both protein dephosphorylation and the regulation of receptor-mediated signaling pathways.;

NCIt note : PTPN6 interacts with, and dephosphorylates, many phosphoproteins involved in hematopoietic cell signaling pathways.;

Details

Origin ID

C26343;

UMLS CUI

C1384543;

Currated CISMeF NLP mapping
- protein tyrosine phosphatase, Non-Receptor type 6 [MeSH Descriptor]
- protein tyrosine phosphatase, Non-Receptor type 6 [MeSH concept]
OMIM relation
- Protein-tyrosine phosphatase, nonreceptor-type, 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTPN6 protein, human [MeSH concept]
- PTPN6 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Non-Receptor Protein Tyrosine Phosphatase Gene [NCIt concept]
- PTPN6 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Hematopoietic Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- Erythropoietin Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
- Ras-Independent Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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