IL3 Signaling Pathway

Preferred Label : IL3 Signaling Pathway;

NCIt related terms : IL 3 signaling pathway;

Alternative definition : BIOCARTA: Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il3Pathway;

Details

Origin ID

C39124;

UMLS CUI

C1512595;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Cytokine Receptor Common Subunit Beta [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-3 Receptor Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
pathway_has_gene_element
- CSF2RB wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL3RA wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- PTPN6 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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