" /> JAK2 wt Allele - CISMeF





Preferred Label : JAK2 wt Allele;

NCIt synonyms : Janus Kinase 2 (A Protein Tyrosine Kinase) wt Allele; THCYT3; JTK10;

NCIt definition : Human JAK2 wild-type allele is located within 9p24 and is approximately 143 kb in length. This allele, which encodes tyrosine-protein kinase JAK2 protein, plays a role in interleukin 3 signal transduction. An allelic variant of the JAK2 gene, which exhibits a dominant gain of function mutation, is associated with several myeloproliferative disorders including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis.;

NCIt note : In a mouse model, absence of JAK2 gene product activity contributes to the absence of definitive erythropoiesis, resulting in embryonic lethality.;

GenBank Accession Number : NM_004972;

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12/05/2024


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