Proto-Oncogene c-Fos

Preferred Label : Proto-Oncogene c-Fos;

NCIt synonyms : c-fos Protein; FBJ Murine Osteosarcoma Viral Oncogene Homolog; FOS; Cellular Oncogene Fos; FOS Protein; G0/G1 Switch Regulatory Protein 7; p55; Cellular Oncogene C-Fos;

NCIt definition : Proto-oncogene c-Fos (380 aa, 41 kDa) is encoded by the human FOS gene. This protein is involved in transcriptional regulation, DNA binding and signal transduction.;

NCIt note : FOS is involved in growth-related transcriptional control, is a key regulator of osteoclast-macrophage lineage determination, and is a major component of the heterodimeric DNA-binding AP-1 transcription factor complex, which includes JUN family members. Both proteins contain a bZIP region. AP-1 binds to TREs (TPA-responsive elements) in the promoters of target genes. (from OMIM 164810);

Details

Origin ID

C17438;

UMLS CUI

C5196775;

OMIM relation
- Fos protooncogene, ap1 transcription factor subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FOS protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FOS Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- B-Cell Survival Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bone Remodeling Pathway [NCIt concept]
- CCR5 Signaling Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Endothelin Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL12/STAT4 Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2-Mediated Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- NTRK1/MAPK Signaling Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- PDGFR-alpha Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Pain Repression Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- Ras Signaling in the CD4+ TCR Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 2 Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
- TSP-1 Induced Apoptosis Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
gene_product_is_physical_part_of
- AP-1 Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Survival [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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