" /> Proto-Oncogene c-Fos - CISMeF





Preferred Label : Proto-Oncogene c-Fos;

NCIt synonyms : c-fos Protein; FBJ Murine Osteosarcoma Viral Oncogene Homolog; FOS; Cellular Oncogene Fos; FOS Protein; G0/G1 Switch Regulatory Protein 7; p55; Cellular Oncogene C-Fos;

NCIt definition : Proto-oncogene c-Fos (380 aa, 41 kDa) is encoded by the human FOS gene. This protein is involved in transcriptional regulation, DNA binding and signal transduction.;

NCIt note : FOS is involved in growth-related transcriptional control, is a key regulator of osteoclast-macrophage lineage determination, and is a major component of the heterodimeric DNA-binding AP-1 transcription factor complex, which includes JUN family members. Both proteins contain a bZIP region. AP-1 binds to TREs (TPA-responsive elements) in the promoters of target genes. (from OMIM 164810);

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30/07/2025


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