Oxidative Stress Pathway

Preferred Label : Oxidative Stress Pathway;

NCIt related terms : Oxidative Stress Induced Gene Expression Via Nrf2;

Alternative definition : BIOCARTA: Reactive oxygen species (ROS) are detrimental to cellular health and can damage biological macromolecules. Electrophilic compounds, xenobiotics and antioxidants are sources of reactive oxygen species, creating oxidative stress that can harm cells. Enzymes involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase. Expression of these genes protects cells from oxidative damage and can prevent mutagenesis and cancer. Transcription of these enzymes is coordinately regulated through antioxidant response elements (AREs). Nrf2 (NF-E2-related factor 2) and Nrf1 are transcription factors that bind to AREs and activate these genes. Inactive Nrf2 is retained in the cytosol by association a complex with the cytoskeletal protein Keap1. Cytosolic Nrf2 is phosphorylated and translocates into the nucleus in response to protein kinase C activation and Map kinase pathways. In the nucleus, Nrf2 activate genes through AREs by interacting with transcription factors in the bZIP family, including CREB, ATF4 and fos or jun. Nrf2 activation of genes is opposed by small maf proteins, including MafG and MafK, maintaining a counterbalance to Nrf2 and balancing the oxidation level of the intracellular environment. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_arenrf2Pathway;

Details

Origin ID

C38990;

UMLS CUI

C1518762;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Aflatoxin B1 Aldehyde Reductase Member 2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Heme Oxygenase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- NADPH-Cytochrome P450 Reductase [NCIt concept]
- Nuclear Factor Erythroid 2-Related Factor 2 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor MafG [NCIt concept]
pathway_has_gene_element
- AKR7A2 wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- HMOX1 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAFG wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- NFE2L2 wt Allele [NCIt concept]
- POR wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]

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