HMOX1 wt Allele

Preferred Label : HMOX1 wt Allele;

NCIt synonyms : Heme Oxygenase (Decycling) 1 wt Allele; HO1; HO;

NCIt definition : Human HMOX1 wild-type allele is located within 22q12 and is approximately 13 kb in length. This allele, which encodes heme oxygenase 1 protein, plays a role in the conversion of heme to bilirubin and carbon monoxide. Certain allelic variants of the HMOX1 gene are associated with heme oxygenase 1 deficiency.;

NCIt note : Polymorphisms in the promoter region of the HMOX1 gene are associated with susceptibility to lung adenocarcinoma and oral squamous cell carcinoma. HMOX1 gene expression is induced by its heme substrate, bromobenzene, endotoxin, heavy metals, oxidizing agents and UV-A radiation.;

GenBank Accession Number : NM_002133;

Details

Origin ID

C50881;

UMLS CUI

C1705268;

OMIM relation
- Heme oxygenase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Squamous Cell Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 22q12 [NCIt concept]
gene_is_element_in_pathway
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- Porphyrin and Chlorophyll Metabolism Pathway [NCIt concept]
gene_plays_role_in_process
- Catabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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