Preferred Label : IL10 Anti-inflammatory Signaling Pathway;
NCIt related terms : IL-10 Anti-inflammatory Signaling Pathway;
Alternative definition : BIOCARTA: IL-10 is a cytokine with potent anti-inflammatory properties, repressing
the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by activated
macrophages. The IL-10 receptor is in the JAK/STAT class of receptors but activation
of the JAK/STAT pathways by IL-10 does not appear on its own to be responsible for
the anti-inflammatory properties of this cytokine. The anti-inflammatory actions of
IL-10 appear to require induction of the enzyme heme oxygenase-1 (HO-1) through a
map kinase pathway involving the p38 kinases. HO-1 is involved in the biosynthesis
of heme, and catalyzes a reaction producing carbon monoxide, free iron, and the heme
precursor biliverdin. HO-1 is induced by IL-10 and is also induced by oxidative stress.
Blocking HO-1 with inhibitors or antisense blocks the anti-inflammatory actions of
IL-10. The anti-inflammatory actions of HO-1 appear to be the result of signaling
by the carbon monoxide it produces since removal of CO blocks the anti-inflammatory
action of IL-10 and HO-1. The anti-inflammatory actions of IL-10 may be therapeutically
useful either directly or through modulation of HO-1 activity. (This definition may
be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_il10Pathway;
Origin ID : C39116;
UMLS CUI : C1512587;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
