IL10 wt Allele

Preferred Label : IL10 wt Allele;

NCIt synonyms : Cytokine Synthesis Inhibitory Factor Gene; TGIF; T-Cell Growth Inhibitory Factor Gene; Interleukin 10 wt Allele; Interleukin-10 Gene; Interleukin 10 Precursor Gene; MGC126450; IL-10; CSIF; GVHDS; RP11-262N9.1; MGC126451; IL10A;

NCIt definition : Human IL10 wild-type allele is located within 1q31-q32 and is approximately 5 kb in length. This allele, which encodes interleukin-10 protein, plays a role in several processes such as immune regulation and inflammation.;

NCIt note : IL10 is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest a putative role as an essential immunoregulator in the intestinal tract.;

GenBank Accession Number : NM_000572;

Details

Origin ID

C49787;

UMLS CUI

C1705004;

Automatic exact mappings (from CISMeF team)
- Graft versus host disease [MedDRA Preferred Term]
- Graft-versus-host disease [ICD-11 Category]
- Graft-versus-host disease, susceptibility to [OMIM Phenotype]
- Interleukin 10 [LOINC component]
- Interleukin 10 [OMIM gene]
- Interleukin-10 [MeSH Descriptor]
- Interleukin-10 (substance) [SNOMED CT concept]
- Transforming growth factor-beta-induced factor [OMIM gene]
- interleukin 10 [ORDO Gene]
- interleukin-10 [Blood Transfusion thesaurus concept]
- interleukin-10 receptor binding [GO term]
OMIM relation
- Interleukin 10 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Acquired Immunodeficiency Syndrome [NCIt concept]
- Crohn Disease [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 10: 203334234-203329343 [NCIt concept]
gene_in_chromosomal_location
- 1q31-q32 [NCIt concept]
gene_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Asthma Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_plays_role_in_process
- B Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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