Amoebiasis Pathway

Preferred Label : Amoebiasis Pathway;

NCIt synonyms : E. histolytica Infection Pathway; Entamoeba histolytica Infection Pathway;

NCIt related terms : Amoebiasis;

Alternative definition : KEGG: Entamoeba histolytica, an extracellular protozoan parasite, is a human pathogen that invades the intestinal epithelium. Infection occurs upon ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection, like amoebic liver abscess, by evading the immune response.;

KEGG ID : hsa05146;

Details

Origin ID

C91808;

UMLS CUI

C2984573;

Automatic exact mappings (from CISMeF team)
- Amebic dysentery (disorder) [SNOMED CT concept]
- Amebic infection (disorder) [SNOMED CT concept]
- Amoebiasis [MedDRA Preferred Term]
- Amoebiasis [ICD-11 Category]
- Infection caused by Entamoeba histolytica (disorder) [SNOMED CT concept]
- amebiasis [DO Concept]
- amebiasis [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- Alpha-Actinin-1 [NCIt concept]
- Alpha-Actinin-4 [NCIt concept]
- Antigen-Presenting Glycoprotein CD1d [NCIt concept]
- Arginase-1 [NCIt concept]
- Arginase-2, Mitochondrial [NCIt concept]
- Caspase-3 [NCIt concept]
- Cathepsin G [NCIt concept]
- Collagen Alpha-1(I) Chain [NCIt concept]
- Collagen Alpha-1(III) Chain [NCIt concept]
- Collagen Alpha-2(I) Chain [NCIt concept]
- Collagen Alpha-2(IV) Chain [NCIt concept]
- Collagen Alpha-3(IV) Chain [NCIt concept]
- Collagen Alpha-6(IV) Chain [NCIt concept]
- Complement Component C6 [NCIt concept]
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
- Complement Component C9 [NCIt concept]
- Fibronectin [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor [NCIt concept]
- Growth-Regulated Alpha Protein [NCIt concept]
- Heat Shock Protein Beta-1 [NCIt concept]
- Integrin Alpha-M [NCIt concept]
- Integrin Beta-2 [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-1 Receptor Type 1 [NCIt concept]
- Interleukin-1 Receptor Type 2 [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-8 [NCIt concept]
- Laminin Subunit Alpha-2 [NCIt concept]
- Laminin Subunit Alpha-3 [NCIt concept]
- Laminin Subunit Beta-2 [NCIt concept]
- Laminin Subunit Gamma-2 [NCIt concept]
- Monocyte Differentiation Antigen CD14 [NCIt concept]
- Mucin-2 [NCIt concept]
- Nitric Oxide Synthase, Inducible [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Ras-Related Protein Rab-5A [NCIt concept]
- Ras-Related Protein Rab-5B [NCIt concept]
- Ras-Related Protein Rab-5C [NCIt concept]
- Ras-Related Protein Rab-7a [NCIt concept]
- Serpin B3 [NCIt concept]
- Serpin B4 [NCIt concept]
- Serpin B9 [NCIt concept]
- Toll-Like Receptor 2 [NCIt concept]
- Toll-Like Receptor 4 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Vinculin [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ACTN1 wt Allele [NCIt concept]
- ACTN4 wt Allele [NCIt concept]
- ARG1 wt Allele [NCIt concept]
- ARG2 wt Allele [NCIt concept]
- C6 wt Allele [NCIt concept]
- C8A wt Allele [NCIt concept]
- C8B wt Allele [NCIt concept]
- C8G wt Allele [NCIt concept]
- C9 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CD14 wt Allele [NCIt concept]
- CD1D wt Allele [NCIt concept]
- COL1A1 wt Allele [NCIt concept]
- COL1A2 wt Allele [NCIt concept]
- COL3A1 wt Allele [NCIt concept]
- COL4A2 wt Allele [NCIt concept]
- COL4A3 wt Allele [NCIt concept]
- COL4A6 wt Allele [NCIt concept]
- CSF2 wt Allele [NCIt concept]
- CTSG wt Allele [NCIt concept]
- CXCL1 wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- FN1 wt Allele [NCIt concept]
- HSPB1 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- IL12A wt Allele [NCIt concept]
- IL12B wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL1R1 wt Allele [NCIt concept]
- IL1R2 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- ITGAM wt Allele [NCIt concept]
- ITGB2 wt Allele [NCIt concept]
- LAMA2 wt Allele [NCIt concept]
- LAMA3 wt Allele [NCIt concept]
- LAMB2 wt Allele [NCIt concept]
- LAMC2 wt Allele [NCIt concept]
- MUC2 wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NOS2 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RAB5A wt Allele [NCIt concept]
- RAB5B wt Allele [NCIt concept]
- RAB5C wt Allele [NCIt concept]
- RAB7A wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- SERPINB3 wt Allele [NCIt concept]
- SERPINB4 wt Allele [NCIt concept]
- SERPINB9 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TLR2 wt Allele [NCIt concept]
- TLR4 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- VCL wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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