Toll-Like Receptor 2

Preferred Label : Toll-Like Receptor 2;

NCIt synonyms : TIL4; Toll/Interleukin 1 Receptor-Like 4; Toll/Interleukin 1 Receptor-Like Protein 4; TLR2; Toll-Like Receptor-2; CD282 Antigen;

NCIt definition : Toll-like receptor 2 (784 aa, 90 kDa) is encoded by the human TLR2 gene. This protein is involved in signal transduction that modulates innate immunity.;

NCIt note : Toll-like receptor (TLR) 2 mediates response to microbial lipoproteins and cell wall components. Binding LY96 and TLR6 via the extracellular domains, TLR2 recognizes MALP-2, STF, PSM, and OspA-L with TLR6. TLR2 acts via MyD88 (via their TIR domains) and TRAF6, activating NF-Kappa-B, cytokine secretion, and inflammatory response. TLR2 may promote apoptosis in response to lipoproteins. (UniProt);

Details

Origin ID

C30102;

UMLS CUI

C0754727;

Currated CISMeF NLP mapping
- Toll-Like receptor 2 [MeSH concept]
- toll-like receptor 2 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TLR2 protein, human [MeSH concept]
- TLR2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Leukocyte [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amoebiasis Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immunity [NCIt concept]
- Inflammatory Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- TLR 2/6/9 Agonist PUL-042 [NCIt concept]
- TLR1/2 Agonist Pam3Cys-GDPKHPKSF [NCIt concept]
- Tomaralimab [NCIt concept]
- Zymosan [NCIt concept]

Keyword's position in hierarchy(ies) :

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