Preferred Label : TLR1/2 Agonist Pam3Cys-GDPKHPKSF;
NCIt synonyms : TLR1/2 Ligand XS15; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)-(2R)-propyl]-(R)-cysteinyl-GDPKHPKSF; TLR1/2 Agonist XS15; Pam3Cys-GDPKHPKSF XS15;
NCIt definition : A vaccine adjuvant and synthetic Toll-like receptor (TLR) type 1 and 2 ligand composed
of a lipopeptide containing a water-soluble derivative of Pam3-Cys, the biologically
active component of the mycobacterial 19 kDa lipoprotein of mycobacteria, that is
covalently linked to a synthetic peptide (GDPKHPKSF), with potential immunostimulating
activity. Upon administration, TLR1/2 agonist Pam3Cys-GDPKHPKSF targets, binds to
and activates TLR1/2, which induces CD8- and T-helper 1 CD4-positive T-cell responses.
This may enhance T-cell-mediated immune responses when administered together with
peptide vaccine.;
Molecule name : XS-15; XS 15;
NCI Metathesaurus CUI : CL1662176;
Origin ID : C179595;
UMLS CUI : C5555800;
Semantic type(s)
- concept_is_in_subset
- has_target
