Toll-Like Receptor 1

Preferred Label : Toll-Like Receptor 1;

NCIt synonyms : TIL; Toll/Interleukin-1 Receptor-Like; TLR1; Toll-Like Receptor-1; CD281 Antigen; Toll/Interleukin-1 Receptor-Like Protein;

NCIt definition : Toll-like receptor 1 (786 aa, 90 kDa) is encoded by the human TLR1 gene. This protein plays a role in antimicrobial immune responses.;

NCIt note : Toll-like receptor (TLR) 1 binds to the TLR2 extracellular domain and cooperates with TLR2 to regulate lipoprotein-dependent inate immunity. TLR1 appears to bind MyD88 via their TIR domains, and to TRAF6, leading to NF-Kappa-B activation, cytokine secretion, and inflammatory responses.;

Details

Origin ID

C30101;

UMLS CUI

C4282042;

Currated CISMeF NLP mapping
- Toll-Like receptor 1 [MeSH concept]
- toll-like receptor 1 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Golgi Apparatus [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immunity [NCIt concept]
- Inflammatory Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- TLR1/2 Agonist Pam3Cys-GDPKHPKSF [NCIt concept]

Keyword's position in hierarchy(ies) :

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