" /> Tomaralimab - CISMeF





Preferred Label : Tomaralimab;

NCIt synonyms : Anti-TLR2 Monoclonal Antibody OPN-305;

NCIt definition : A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2), with potential anti-inflammatory and antineoplastic activities. Upon intravenous administration, tomaralimab binds to the ligand-binding site on the TLR2 receptor and blocks the activation of TLR2-mediated innate immunity signaling. This prevents the TLR2-mediated production of pro-inflammatory mediators and prevents inflammation. TLR2, a member of the TLR family primarily found on leukocytes, plays a key role in the activation of innate immunity; it is overexpressed in various inflammatory diseases and in certain types of cancer.;

UNII : P45C2W27DU;

CAS number : 1449294-76-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1449294-76-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : OPN-305;

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16/05/2024


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