Preferred Label : TLR 2/6/9 Agonist PUL-042;
NCIt synonyms : Pam2CSK4 Acetate/ODN M362 Combination; Inhalation Solution PUL-042; Pam2/M362; Toll-like Receptor Agonist PUL-042; Solution PUL-042; TLR Agonist PUL-042; Pam2CSK4 Acetate/ODN M362; Pam2/M362 Combination;
NCIt definition : A solution consisting of a combination of two toll-like receptor (TLR) ligands: Pam2CSK4
acetate (Pam2), a synthetic diacylated lipopeptide (LP) that is an agonist of TLR2
and TLR6 (TLR2/6) and the TLR9 agonist oligodeoxynucleotide (ODN) M362, which contains
unmethylated CpG-based dinucleotides, with potential immunostimulating activity. Upon
administration via inhalation of the PUL-042 solution, the components in PUL-042 bind
to and activate TLRs on lung epithelial cells. This induces the epithelial cells to
produce peptides and reactive oxygen species (ROS) against pathogens, including bacteria,
fungi and viruses, that are present in the lungs. M362, through binding of the CpG
motifs to TLR9 and subsequent TLR9-mediated signaling, initiates the innate immune
system and activates macrophages, natural killer (NK) cells, B-cells, and plasmacytoid
dendritic cells (pDCs), stimulates interferon-alpha (IFN-a) production and induces
a T-helper 1 cells (Th1)-mediated immune response. Pam2CSK4, through TLR2/6, activates
the production of T-helper 2 cells (Th2), leading to the production of Th2-specific
cytokines. Altogether, this protects against and kills the pathogens present in the
lungs and prevents pulmonary infection. TLRs play fundamental roles in both pathogen
recognition and the activation of innate immunity.;
Molecule name : PUL 042; PUL-042;
NCI Metathesaurus CUI : CL522529;
Origin ID : C135091;
UMLS CUI : C4525627;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
