Toll-Like Receptor 6

Preferred Label : Toll-Like Receptor 6;

NCIt synonyms : TLR6; CD286 Antigen; Toll-Like Receptor-6;

NCIt definition : Toll-like receptor 6 (796 aa, 92 kDa) is encoded by the human TLR6 gene. This protein is involved in the modulation of the innate immune response to Gram-positive bacteria and fungi.;

NCIt note : Toll-like receptor (TLR) 6, bound to the extracellular domain of TLR2, mediates cellular response to fungi and bacterial lipoproteins MALP-2, STF, PSM, and OspA-L. TLR6 acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response.;

Details

Origin ID

C30107;

UMLS CUI

C1434467;

Currated CISMeF NLP mapping
- Toll-Like receptor 6 [MeSH concept]
- toll-like receptor 6 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TLR6 protein, human [MeSH Supplementary Concept]
- TLR6 protein, human [MeSH concept]
- Toll-Like receptor 6 [MeSH concept]
- toll-like receptor 6 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR6 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chagas Disease Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antimicrobial Effect [NCIt concept]
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- TLR 2/6/9 Agonist PUL-042 [NCIt concept]

Keyword's position in hierarchy(ies) :

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