Growth-Regulated Alpha Protein

Preferred Label : Growth-Regulated Alpha Protein;

NCIt synonyms : Neutrophil Activating Protein 3; CXC Chemokine Ligand 1; CXCL1; GRO Protein, Alpha; MGSA, Alpha; MGSA; NAP-3; Melanoma Growth Stimulating Activity, Alpha; GRO1 Protein; GRO; GROA Protein; MGSA Alpha; Chemokine (C-X-C Motif) Ligand 1; Neutrophil-Activating Protein 3; Melanoma Growth Stimulatory Activity; C-X-C Motif Chemokine Ligand-1; Fibroblast Secretory Protein; C-X-C Motif Chemokine 1; GRO-Alpha(1-73); Melanoma Growth Stimulatory Activity Alpha;

NCIt definition : Growth-regulated alpha protein (107 aa, 11 kDa) is encoded by the human CXCL1 gene. This protein plays a role in neutrophil chemotaxis.;

NCIt note : There are 3 N-terminal processed forms of growth regulated protein alpha: GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73), which are produced by proteolytic cleavage following secretion of the full-length protein from peripheral blood monocytes. (UniProt);

Details

Origin ID

C20471;

UMLS CUI

C0131875;

OMIM relation
- Chemokine, cxc motif, ligand 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CXCL1 protein, human [MeSH concept]
- CXCL1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CXC Cytokine Gene [NCIt concept]
- CXCL1 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- Amoebiasis Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Cutaneous Melanoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
- Melanogenesis [NCIt concept]
is_target
- CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes [NCIt concept]

Keyword's position in hierarchy(ies) :

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