NCIt definition : A preparation of autologous tumor infiltrating lymphocytes (TILs) that are transduced,
ex vivo, with a retroviral vector encoding a gene for CXC chemokine receptor 2 (CXCR2),
with potential antineoplastic activity. Upon administration of the CXCR2-transduced
autologous TILs, the CXCR2-expressing T-cells selectively migrate toward tumor cells
expressing CXCR2 ligands, which leads to tumor cell killing. CXCR2 expression allows
for optimal TIL migration towards tumor cells and enhances the TILs anti-tumor activity.
This leads to a reduction in both tumor cell proliferation and survival. CXCR2, a
transmembrane protein also known as IL-8 receptor B (IL-8RB), plays a key role in
inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8
(IL-8), are expressed by tumor cells.;