NCIt definition : Human IL12B wild-type allele is located within 5q31.1-q33.1 and is approximately 16
kb in length. This allele, which encodes interleukin-12 beta chain protein, plays
a role in promoting the growth of both T cells and natural killer cells. It is also
involved in the differentiation of both Th1 and Th2 cells. Overexpression of the IL12B
gene is associated with multiple sclerosis. A polymorphism in the promoter region
of this gene is associated with the severity of both atopic and non-atopic asthma
in children. Heritable defects in the IL12B gene are a cause of susceptibility to
mycobacterial disease.;
NCIt note : Certain polymorphisms in the IL12B gene may affect the final steps in gastric carcinogenesis
in patients with H. pylori infection.;