Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform

Preferred Label : Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform;

NCIt synonyms : PIK3CB; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Beta Isoform; PtdIns-3-Kinase p110; EC 2.7.1.153; PI3KBeta; PI3-Kinase p110 Subunit Beta; Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Beta; PI3K; p110-Beta; Phosphatidylinositol 3-Kinase, Catalytic, Beta; PI3-Kinase Subunit Beta; PI3K-Beta; Phosphoinositide-3-Kinase Catalytic Beta Polypeptide; Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide; PIK3-Beta; PtdIns-3-Kinase Subunit P110-Beta; Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Beta; PtdIns-3-Kinase Subunit Beta; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Beta;

NCIt definition : Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (1070 aa, 123 kDa) is encoded by the human PIK3CB gene. This protein is involved in both lipid modification and signaling.;

Details

Origin ID

C30170;

UMLS CUI

C1566348;

Automatic exact mappings (from CISMeF team)
- 1-phosphatidylinositol-3-kinase activity [GO term]
- Phosphatidylinositol 3-kinase, catalytic, beta [OMIM gene]
- Pik3cg protein, mouse [MeSH Supplementary Concept]
- class ia phosphatidylinositol 3-Kinase [MeSH Descriptor]
- class ia phosphatidylinositol 3-Kinase, p110beta subunit [MeSH concept]
- phosphatidylinositol 3-Kinase [MeSH Descriptor]
- phosphatidylinositol 3-Kinases [MeSH Descriptor]
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ORDO Gene]
OMIM relation
- Phosphatidylinositol 3-kinase, catalytic, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PIK3CB protein, human [MeSH Supplementary Concept]
- PIK3CB protein, human [MeSH concept]
- class ia phosphatidylinositol 3-Kinase, p110beta subunit [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PIK3CB Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Inositol Phosphate Metabolism Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_is_physical_part_of
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Acalisib [NCIt concept]
- BRAFV600/PI3K Inhibitor ASN003 [NCIt concept]
- PI3K Alpha/Beta Inhibitor BAY1082439 [NCIt concept]
- PI3K p110beta/delta Inhibitor KA2237 [NCIt concept]
- PI3K-beta Inhibitor GSK2636771 [NCIt concept]
- PI3K-beta Inhibitor SAR260301 [NCIt concept]
- PI3Kbeta Inhibitor AZD8186 [NCIt concept]

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