Tumor Necrosis Factor

Preferred Label : Tumor Necrosis Factor;

NCIt synonyms : TNF-Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2; Tumor Necrosis Factor-alpha (macrophage-derived); TNFA; TNF Alpha; Tumor Necrosis Factor Alpha; TNF; TNF-A; Tumor Necrosis Factor-Alpha;

NCIt definition : Tumor necrosis factor (233 aa, 26 kDa) is encoded by the human TNF gene. This protein is involved in the induction of cytokine expression, the stimulation of cell proliferation and the positive regulation of cell differentiation.;

NCIt note : Tumor necrosis factor (TNF) is a serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes which has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants.;

Details

Origin ID

C20535;

UMLS CUI

C1448177;

Automatic exact mappings (from CISMeF team)
- Tumor necrosis factor [OMIM gene]
- Tumor necrosis factor (TNF superfamily, member 2) [ORDO Gene]
- lymphotoxin-beta [MeSH Descriptor]
- tumor necrosis factor [HGNC gene]
- tumor necrosis factor receptor binding [GO term]
Currated CISMeF NLP mapping
- Alpha tumor necrosis factor [MedDRA LLT]
- Alpha tumour necrosis factor [MedDRA Preferred Term]
- Tumor necrosis factor [LOINC component]
- Tumor necrosis factor.alpha [LOINC component]
- tumor necrosis factor [Artificial nutrition thesaurus concept]
- tumor necrosis factor [SNOMED Notion]
- tumor necrosis factor alpha [COVID-19 Thesaurus concept]
- tumor necrosis factor alpha [SNOMED Notion]
- tumor necrosis factor-alpha [MeSH Descriptor]
- tumor necrosis factor-alpha [MeSH concept]
- tumor necrosis factors [MeSH concept]
False automatic mappings
- Tumor necrosis factor (substance) [SNOMED CT concept]
- Tumor necrosis factor alpha (substance) [SNOMED CT concept]
- tumor necrosis factor (1-12) [MeSH concept]
- tumor necrosis factor (1-12) [MeSH Supplementary Concept]
- tumor necrosis factor (1-26) [MeSH concept]
- tumor necrosis factor (1-26) [MeSH Supplementary Concept]
- tumor necrosis factor (41-62) [MeSH concept]
- tumor necrosis factor (41-62) [MeSH Supplementary Concept]
- tumor necrosis factor (78-96) [MeSH concept]
- tumor necrosis factor (78-96) [MeSH Supplementary Concept]
- tumor necrosis factor alpha (36-68) [MeSH concept]
- tumor necrosis factor alpha (36-68) [MeSH Supplementary Concept]
- tumor necrosis factor alpha (70-80) [MeSH concept]
- tumor necrosis factor alpha (70-80) [MeSH Supplementary Concept]
OMIM relation
- Tumor necrosis factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TNF protein, human [MeSH concept]
- TNF protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- tumor necrosis factors [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- TNF Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Apoptosis Regulator [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- Allograft Rejection Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Antigen Processing and Presentation Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Asthma Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Canonical NF-kappaB Signaling Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- Cellular Anthrax Toxin Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Free Radical Induced Apoptosis Pathway [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- Granulocyte Adhesion Pathway [NCIt concept]
- HDAC Class I Signaling Pathway [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- HSP27 Regulation Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Interferon Signaling Modulation Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Macrophage Stimulating 1 Receptor Signaling Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Metabolic Syndrome Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- RELA Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway [NCIt concept]
- SODD/TNFR1 Signaling Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- TNF Stress Related Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Apoptosis [NCIt concept]
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Signal Induction [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Etanercept [NCIt concept]
- Golimumab [NCIt concept]
- Infliximab [NCIt concept]
- Lenalidomide [NCIt concept]
- Thalidomide [NCIt concept]

Keyword's position in hierarchy(ies) :

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