Preferred Label : Integrin Alpha-M;
NCIt synonyms : MO1 Alpha; ITGAM; CD11b; MAC1 Alpha; Neutrophil Adherence Receptor; Complement Receptor Type 3, Alpha Subunit; Cell Surface Glycoprotein MAC-1 Subunit Alpha; CD11b Antigen; Macrophage Antigen Alpha Polypeptide; Integrin Alpha M; Neutrophil Adherence Receptor Alpha-M Subunit; CD11 Antigen-Like Family Member B; CR-3 Alpha Chain; Leukocyte Adhesion Receptor MO1;
NCIt definition : Integrin alpha-M (1152 aa, 127 kDa) is encoded by the human ITGAM gene. This protein
is involved in both leukocyte adhesion and the phagocytosis of complement coated particles.;
NCIt note : An adhesion-promoting leukocyte surface integrin heterodimer contains an alpha subunit
of CD11b antigen and a beta subunit of CD18 antigen. The heterodimer functions as
a receptor for complement 3, and in cell-cell and cell-substrate adhesive interactions.
Major surface antigens on leukocytes include CR3A, LFA-1, and p150,95, which share
a common beta chain linked to one of three alpha distinctive chains. They promote
adhesion of granulocytes to each other and to endothelial cells. The CR3A alpha subunit
(CD11b) is homologous to the alpha subunit of IIb/IIIa, a platelet glycoprotein that
also serves adhesive functions. CD11b also exhibits significant homology with portions
of the alpha subunits of fibronectin, vitronectin, platelet IIb/IIIa receptors, and
p150,95. The protein consists of an N-terminal extracytoplasmic domain, a transmembrane
segment, and a short C-terminal cytoplasmic domain.;
Origin ID : C17373;
UMLS CUI : C1701032;
Automatic exact mappings (from CISMeF team)
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_type
- gene_product_is_element_in_pathway
- gene_product_is_physical_part_of
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
- is_target
