" /> CD11b Agonist GB1275 - CISMeF





Preferred Label : CD11b Agonist GB1275;

NCIt synonyms : Integrin CD11b Agonist GB1275; Integrin Alpha-M Agonist GB1275;

NCIt related terms : ADH-503;

NCIt definition : An orally bioavailable small molecule agonist of CD11b (integrin alpha-M; ITGAM; integrin alpha M chain), with potential immunomodulating activity. Upon administration, CD11b agonist GB1275 targets and binds to CD11b, thereby activating CD11b. This leads to CD11b-mediated signaling and promotes pro-inflammatory macrophage polarization while suppressing immunosuppressive macrophage polarization. This reduces influx of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME), promotes anti-tumor immune responses, induces cytotoxic T-lymphocytes (CTLs) and suppresses tumor growth. CD11b, a member of the integrin family of cell adhesion receptors highly expressed on immune system cells, is a negative regulator of immune suppression and activates anti-tumor innate immunity.;

UNII : THN3VQ67CA;

CAS number : 2055362-72-4;

Molecule name : GB 1275; GB-1275; ADH-503; ADH 503;

NCI Metathesaurus CUI : CL978817;

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09/05/2025


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