Preferred Label : CD11b Agonist GB1275;
NCIt synonyms : Integrin CD11b Agonist GB1275; Integrin Alpha-M Agonist GB1275;
NCIt definition : An orally bioavailable small molecule agonist of CD11b (integrin alpha-M; ITGAM; integrin
alpha M chain), with potential immunomodulating activity. Upon administration, CD11b
agonist GB1275 targets and binds to CD11b, thereby activating CD11b. This leads to
CD11b-mediated signaling and promotes pro-inflammatory macrophage polarization while
suppressing immunosuppressive macrophage polarization. This reduces influx of tumor-associated
macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment
(TME), promotes anti-tumor immune responses, induces cytotoxic T-lymphocytes (CTLs)
and suppresses tumor growth. CD11b, a member of the integrin family of cell adhesion
receptors highly expressed on immune system cells, is a negative regulator of immune
suppression and activates anti-tumor innate immunity.;
Molecule name : GB 1275; GB-1275;
NCI Metathesaurus CUI : CL978817;
Origin ID : C165605;
UMLS CUI : C5237303;
Semantic type(s)
- concept_is_in_subset
- has_target
