PRKCA wt Allele

Preferred Label : PRKCA wt Allele;

NCIt synonyms : Protein Kinase C, Alpha Gene; PKCA; PRKACA; Aging-Associated Gene 6; PKCalpha; Protein Kinase C Alpha wt Allele; AAG6; PKC-alpha;

NCIt definition : Human PRKCA wild-type allele is located within 17q22-q23.2 and is approximately 508 kb in length. This allele, which encodes protein kinase C alpha type protein, is involved in the phosphorylation of diverse protein substrates in response to activation by calcium or the second messenger diacylglycerol. The PRKCA gene is overexpressed in certain types of cancer such as breast tumors, glioblastomas, pituitary tumors and thyroid neoplasms.;

NCIt note : The PRKCA gene is overexpressed in pituitary tumors and a specific functional point mutation in this gene increases the invasiveness of these tumors.;

GenBank Accession Number : NM_002737;

Details

Origin ID

C51271;

UMLS CUI

C1706143;

OMIM relation
- Protein kinase C, alpha [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 17q22-q23.2 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Chordoid Glioma [NCIt concept]
- Papillary Glioneuronal Tumor [NCIt concept]
gene_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Angiogenesis Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Attenuation of GPCR Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- CCR3 Signaling Pathway [NCIt concept]
- CCR5 Signaling Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- CXCR4 Signaling Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Calcineurin Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Canonical NF-kappaB Signaling Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Gastric Acid Secretion Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Ion Channel and Phorbal Esters Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Myosin Phosphatase Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Nitric Oxide Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
- Phospholipase C Signaling Pathway [NCIt concept]
- Phospholipid Associated Cell Signaling Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Protein Kinase C Activation Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Ras Signaling in the CD4+ TCR Pathway [NCIt concept]
- SRC Tyrosine Kinase Activation Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
- Thrombin/Protease-Activated Receptor Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
- Trka Receptor Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- VEGFR1 Signaling Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
- Vibrio cholerae Infection Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
- eIF4 Regulation Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
gene_plays_role_in_process
- Calcium Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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