Apoptosis DNA Damage Pathway

Preferred Label : Apoptosis DNA Damage Pathway;

NCIt related terms : Apoptotic Signaling in Response to DNA Damage;

Alternative definition : BIOCARTA: The cellular activation of the caspase cascade resulting in cell death is triggered by chemical damage to DNA which stimulates a sequence resulting in the cleavage of BID or directly initiates the permeability transition of the mitochondrial membrane. The permeability transition releases several factors including cytochrome c, AIF and other factors in to the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase cascade. The caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_chemicalPathway;

Details

Origin ID

C39028;

UMLS CUI

C1516042;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Activated Caspase-3 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Apoptosis Regulator BAX [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Bcl-2-Like Protein 1 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Truncated BID [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- APAF1 wt Allele [NCIt concept]
- ATM wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BAX wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- BCL2L1 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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