Apoptosis Regulator BAX

Preferred Label : Apoptosis Regulator BAX;

NCIt synonyms : BCL2-Associated X Protein; BAX Protein; BAX Isoform Alpha; BAX; Bcl2-L-4; Bcl-2-Like Protein 4;

NCIt definition : Apoptosis regulator BAX (192 aa, 21 kDa) is encoded by the human BAX gene. This protein plays a role in both apoptosis and protein-protein interactions.;

NCIt note : The BAX gene produces at least four proteins by alternate splicing: membrane-bound alpha and cytoplasmic beta, gamma, and delta; all bind and antagonize BCL2, which represses programmed cell death. Pro-apoptotic BAX acts as a partner of BCL2, shows extensive homology with BCL2, and forms homodimers and heterodimers with BCL2. Pro-apoptotic BAX and BAK proteins accelerate opening of the mitochondrial porin channel, VDAC. BAX appears to interact, and cooperate, with the constitutive pro-apoptotic ANT mitochondrial protein within the pore complex to increase mitochondrial permeability, allowing cytochrome C passage and triggering cell death. Expression of BAX is a significant prognostic factor in patients with gastric lymphoma. Its prognostic value increases significantly when studied in BCL2-negative patients. (from OMIM 600040 and NCI);

Details

Origin ID

C17699;

UMLS CUI

C1528509;

Currated CISMeF NLP mapping
- bax protein (53-86) [MeSH concept]
- bax protein (53-86) [MeSH Supplementary Concept]
OMIM relation
- Bcl2-associated X protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BAX protein, human [MeSH Supplementary Concept]
- BAX protein, human [MeSH concept]
- bcl-2-Associated X protein [MeSH concept]
- bcl-2-Associated X protein [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BAX Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Ligand Binding Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH1 Domain [NCIt concept]
- BH2 Domain [NCIt concept]
- BH3 Domain [NCIt concept]
gene_product_is_biomarker_type
- Prognostic Marker [NCIt concept]
gene_product_is_element_in_pathway
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- BAD Regulation Pathway [NCIt concept]
- Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- HDAC Class III Signaling Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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