Preferred Label : BH2 Domain;
NCIt synonyms : BCL-2 Homology 2 Domain;
NCIt definition : Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4)
Domains are critical to protein apoptotic function and the protein ability to interact/dimerize
with other family members or regulatory proteins. BCL-2 family proteins dimerize among
pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve
head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and
BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction
of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress
cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation.
(NCI);
Origin ID : C13913;
UMLS CUI : C1511011;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
