Bcl-2-Like Protein 12

Preferred Label : Bcl-2-Like Protein 12;

NCIt synonyms : Bcl-2 Related Proline-Rich Protein; Bcl-2-Related Proline-Rich Protein; Bcl2-L-12;

NCIt definition : Bcl-2-like protein 12 (334 aa, 37 kDa) is encoded by the human BCL2L12 gene. This protein is involved in the inhibition of apoptosis.;

NCIt note : Bcl-2-like protein 12 inhibits apopotosis through the inhibition of both p53-mediated gene expression in the nucleus and the proteolytic activity of caspase 3 and 7 in the cytoplasm. (EntrezGene);

Details

Origin ID

C114745;

UMLS CUI

C1309992;

Automatic exact mappings (from CISMeF team)
- Bcl2-like 12 [OMIM gene]
OMIM relation
- Bcl2-like 12 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BCL2L12 protein, human [MeSH Supplementary Concept]
- BCL2L12 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BCL2L12 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Inhibitor [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH2 Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
is_target
- Spherical Nucleic Acid Nanoparticle NU-0129 [NCIt concept]

Keyword's position in hierarchy(ies) :

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