Spherical Nucleic Acid Nanoparticle NU-0129

Preferred Label : Spherical Nucleic Acid Nanoparticle NU-0129;

NCIt synonyms : SNA Gold Nanoparticle NU-0129; SNA NU-0129;

NCIt definition : A spherical nucleic acid (SNA) gold nanoparticle formulation composed of small interfering RNAs (siRNAs) targeting the Bcl-2-like protein 12 (BCL2L12) sequence and conjugated to gold nanoparticles, with potential antineoplastic activity. Upon administration of SNA NU-0129, the siRNA prevents the translation of the BCL2L12 gene. Inhibiting the expression of BCL2L12 by NU-0129 induces tumor cell apoptosis. Bcl2L12, a protein belonging to the Bcl-2 protein family, is overexpressed in glioblastoma multiforme (GBM) and plays a role in tumor cell progression and tumor cell resistance to apoptosis. NU-0129 is able to cross the blood brain barrier (BBB).;

Molecule name : NU-0129;

NCI Metathesaurus CUI : CL514431;

Details

Origin ID

C131368;

UMLS CUI

C4331306;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Bcl-2-Like Protein 12 [NCIt concept]

Keyword's position in hierarchy(ies) :

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