Bcl-2 Homologous Antagonist/Killer

Preferred Label : Bcl-2 Homologous Antagonist/Killer;

NCIt synonyms : Bcl2-L-7; Apoptosis Regulator BAK; BAK1; Cell Death Inhibitor 1; Bcl-2-Like Protein 7; BCL2-Antagonist/Killer 1; BCL2-Antagonist Killer-1;

NCIt definition : Bcl-2 homologous antagonist/killer (211 aa, 23 kDa) is encoded by the human BAK1 gene. This protein is involved in both protein-protein interactions and apoptosis.;

NCIt note : A BCL2 related protein that induces apoptosis. May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary);

Details

Origin ID

C21192;

UMLS CUI

C1530764;

OMIM relation
- Bcl2 antagonist killer 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BAK1 protein, human [MeSH Supplementary Concept]
- BAK1 protein, human [MeSH concept]
- bcl-2 homologous Antagonist-Killer protein [MeSH concept]
- bcl-2 homologous Antagonist-Killer protein [MeSH Descriptor]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BAK1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH1 Domain [NCIt concept]
- BH2 Domain [NCIt concept]
- BH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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