Mitochondria in Apoptotic Signaling Pathway

Preferred Label : Mitochondria in Apoptotic Signaling Pathway;

NCIt related terms : Role of Mitochondria in Apoptotic Signaling;

Alternative definition : BIOCARTA: Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochrome c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_mitochondriaPathway;

Details

Origin ID

C39154;

UMLS CUI

C1513340;

Semantic type(s)
- Genetic Function [UMLS semantic type]
has_gene_product_element
- Activated Caspase-9 [NCIt concept]
- Apoptosis Regulator BAX [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- Bcl-2 Homologous Antagonist/Killer [NCIt concept]
- Bcl-2-Interacting Killer [NCIt concept]
- Bcl-2-Like Protein 1 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- Diablo IAP-Binding Mitochondrial Protein [NCIt concept]
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]
pathway_has_gene_element
- APAF1 wt Allele [NCIt concept]
- BAK1 wt Allele [NCIt concept]
- BAX wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- BCL2L1 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- BIK wt Allele [NCIt concept]
- BIRC2 wt Allele [NCIt concept]
- BIRC3 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- DIABLO wt Allele [NCIt concept]
- XIAP wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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