Caspase-7 - CISMeF

Preferred Label : Caspase-7;

NCIt synonyms : ICE-LAP3; Caspase 7; ICE-Like Apoptotic Protease 3; CASP7 protein; MCH3; Apoptotic Protease Mch-3; Caspase 7, Apoptosis-Related Cysteine Protease; CMH-1; CASP7; EC 3.4.22.60; CASP-7;

NCIt definition : Caspase-7 (303 aa, 34 kDa) is encoded by the human CASP7 gene. This protein is involved in caspase-mediated apoptosis and proteolysis.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.;

Details

Origin ID

C28439;

UMLS CUI

C1307660;

Automatic exact mappings (from CISMeF team)
- 3C-like protease, rabbit hemorrhagic disease virus [MeSH Supplementary Concept]
- A1494 protein, arabidopsis [MeSH Supplementary Concept]
- ATG4A protein, human [MeSH Supplementary Concept]
- ATG4B protein, human [MeSH Supplementary Concept]
- ATG4D protein, human [MeSH Supplementary Concept]
- ATP-activated high molecular mass proteinase I [MeSH Supplementary Concept]
- ATXN3 protein, human [MeSH Supplementary Concept]
- AsNODf32 protein, astragalus sinicus [MeSH Supplementary Concept]
- At1g09730 protein, arabidopsis [MeSH Supplementary Concept]
- At3g48480 protein, arabidopsis [MeSH Supplementary Concept]
- At4g33620 protein, arabidopsis [MeSH Supplementary Concept]
- Atg4C protein, mouse [MeSH Supplementary Concept]
- C3-cleaving proteinase, 39 kDa [MeSH Supplementary Concept]
- CALPx11 protein, trypanosoma cruzi [MeSH Supplementary Concept]
- CAP5.5 protein, trypanosoma brucei [MeSH Supplementary Concept]
- CAPN11 protein, human [MeSH Supplementary Concept]
- CAPN12 protein, human [MeSH Supplementary Concept]
- CAPN2 protein, human [MeSH Supplementary Concept]
- CAPN3 protein, human [MeSH Supplementary Concept]
- CAPN8 protein, Xenopus [MeSH Supplementary Concept]
- CAPN9 protein, human [MeSH Supplementary Concept]
- CAPN9 protein, rat [MeSH Supplementary Concept]
- CAPNS1 protein, human [MeSH Supplementary Concept]
- CASP14 protein, human [MeSH Supplementary Concept]
- CASP2 protein, human [MeSH Supplementary Concept]
- CASP3 protein, human [MeSH Supplementary Concept]
- CASP4 protein, human [MeSH Supplementary Concept]
- CASP5 protein, human [MeSH Supplementary Concept]
- CASP6 protein, human [MeSH Supplementary Concept]
- CASP7 protein, human [MeSH Supplementary Concept]
- CASP8 protein, human [MeSH Supplementary Concept]
- CASP9 protein, human [MeSH Supplementary Concept]
- CPPIC protein, zea mays [MeSH Supplementary Concept]
- CPa protein, leishmania mexicana [MeSH Supplementary Concept]
- CTSW protein, human [MeSH Supplementary Concept]
- CV-1 SPase [MeSH Supplementary Concept]
- CYP15a protein, pisum sativum [MeSH Supplementary Concept]
- CalpB protein, drosophila [MeSH Supplementary Concept]
- Capn11 protein, mouse [MeSH Supplementary Concept]
- Capn12 protein, mouse [MeSH Supplementary Concept]
- Capn3 protein, mouse [MeSH Supplementary Concept]
- Capn3 protein, rat [MeSH Supplementary Concept]
- Capn5 protein, human [MeSH Supplementary Concept]
- Capn5 protein, mouse [MeSH Supplementary Concept]
- Capn6 protein, mouse [MeSH Supplementary Concept]
- Capn7 protein, human [MeSH Supplementary Concept]
- Capn7 protein, mouse [MeSH Supplementary Concept]
- Capn8 protein, mouse [MeSH Supplementary Concept]
- Capns1 protein, mouse [MeSH Supplementary Concept]
- Cardiomyopathy, familial hypertrophic, 1 [OMIM Phenotype]
- Casp14 protein, mouse [MeSH Supplementary Concept]
- Casp2 protein, mouse [MeSH Supplementary Concept]
- Casp2 protein, rat [MeSH Supplementary Concept]
- Casp3 protein, mouse [MeSH Supplementary Concept]
- Casp3 protein, rat [MeSH Supplementary Concept]
- Casp4 protein, mouse [MeSH Supplementary Concept]
- Casp4 protein, rat [MeSH Supplementary Concept]
- Casp6 protein, mouse [MeSH Supplementary Concept]
- Casp6 protein, rat [MeSH Supplementary Concept]
- Casp7 protein, mouse [MeSH Supplementary Concept]
- Casp8 protein, mouse [MeSH Supplementary Concept]
- Casp8 protein, rat [MeSH Supplementary Concept]
- Casp9 protein, mouse [MeSH Supplementary Concept]
- Casp9 protein, rat [MeSH Supplementary Concept]
- Caspase 7, apoptosis-related cysteine protease [OMIM gene]
- CprD protein, dicytostelium [MeSH Supplementary Concept]
- CprE protein, dictyostelium discoideum [MeSH Supplementary Concept]
- Cwp84 protein, clostridium difficile [MeSH Supplementary Concept]
- DAMM protein, drosophila [MeSH Supplementary Concept]
- DCCP1 protein, dianthus caryophyllus [MeSH Supplementary Concept]
- DEK1 protein, arabidopsis [MeSH Supplementary Concept]
- Dcp-1 protein, drosophila [MeSH Supplementary Concept]
- ELS1 protein, arabidopsis [MeSH Supplementary Concept]
- EPB1 protein, hordeum vulgare [MeSH Supplementary Concept]
- EPB2 protein, hordeum vulgare [MeSH Supplementary Concept]
- ER-60 protease [MeSH Supplementary Concept]
- ESD4 protein, arabidopsis [MeSH Supplementary Concept]
- EhCP112 protein, entamoeba histolytica [MeSH Supplementary Concept]
- Fas2 antigen, fasciola hepatica [MeSH Supplementary Concept]
- GFLV VP7 proteinase [MeSH Supplementary Concept]
- HC-Pro protein, potyvirus [MeSH Supplementary Concept]
- HCNP-processing enzyme [MeSH Supplementary Concept]
- HSP31 protein, S cerevisiae [MeSH Supplementary Concept]
- KGP-381 protein, porphyromonas gingivalis [MeSH Supplementary Concept]
- L3 23K protein, adenovirus [MeSH Supplementary Concept]
- Ldccys1 protein, leishmania chagasi [MeSH Supplementary Concept]
- Ldccys2 protein, leishmania chagasi [MeSH Supplementary Concept]
- LmCPb protein, leishmania mexicana [MeSH Supplementary Concept]
- MALT1 protein, human [MeSH Supplementary Concept]
- MC1 protein, arabidopsis [MeSH Supplementary Concept]
- MC2 protein, arabidopsis [MeSH Supplementary Concept]
- MCA-1 protein, plasmodium falciparum [MeSH Supplementary Concept]
- MCA1 protein, S cerevisiae [MeSH Supplementary Concept]
- MCA3 protein, trypanosoma cruzi [MeSH Supplementary Concept]
- MCA5 protein, trypanosoma cruzi [MeSH Supplementary Concept]
- MCP1b protein, arabidopsis [MeSH Supplementary Concept]
- MCP2b protein, arabidopsis [MeSH Supplementary Concept]
- Mc27 protein, paragonimus westermani [MeSH Supplementary Concept]
- Mc28 protein, paragonimus westermani [MeSH Supplementary Concept]
- N-benzyloxycarbonylglycyl-glycyl-arginyl peptidase [MeSH Supplementary Concept]
- NS2-3 protease [MeSH Supplementary Concept]
- Ndel1 protein, rat [MeSH Supplementary Concept]
- Nep1 protein, S pombe [MeSH Supplementary Concept]
- OTS1 protein, arabidopsis [MeSH Supplementary Concept]
- OTS2 protein, arabidopsis [MeSH Supplementary Concept]
- OTUB1 protein, human [MeSH Supplementary Concept]
- Otub1 protein, mouse [MeSH Supplementary Concept]
- PSMB4 protein, human [MeSH Supplementary Concept]
- PalB protein, aspergillus nidulans [MeSH Supplementary Concept]
- PePer1 protein, petunia hybrida [MeSH Supplementary Concept]
- PrtH protein, bacteria [MeSH Supplementary Concept]
- PrtRII50 protein, porphyromonas gingivalis [MeSH Supplementary Concept]
- RCE1 protein, human [MeSH Supplementary Concept]
- Rce1 protein, mouse [MeSH Supplementary Concept]
- S-carboxamido-papain [MeSH Supplementary Concept]
- S-carboxymethyl-papain [MeSH Supplementary Concept]
- S-methylthio-papain [MeSH Supplementary Concept]
- SCPc1 protein, sitophilus zeamais [MeSH Supplementary Concept]
- SCPg3 protein, sitophilus zeamais [MeSH Supplementary Concept]
- SEN102 protein, hemerocallis [MeSH Supplementary Concept]
- SENP2 protein, human [MeSH Supplementary Concept]
- SENP3 protein, human [MeSH Supplementary Concept]
- SENP6 protein, human [MeSH Supplementary Concept]
- SENP7 protein, human [MeSH Supplementary Concept]
- SENP7 protein, mouse [MeSH Supplementary Concept]
- SENP8 protein, human [MeSH Supplementary Concept]
- STRICA protein, Drosophila [MeSH Supplementary Concept]
- SUSP4 protein, mouse [MeSH Supplementary Concept]
- Sm31 protein, schistosoma mansoni [MeSH Supplementary Concept]
- SmCL2 protein, schistosoma mansoni [MeSH Supplementary Concept]
- SmTP1 protein, sarcocystis muris [MeSH Supplementary Concept]
- TbcatB protein, trypanosoma brucei [MeSH Supplementary Concept]
- Tc-cpl-1 protein, toxocara canis [MeSH Supplementary Concept]
- Tnfaip3 protein, mouse [MeSH Supplementary Concept]
- Tysnd1 protein, rat [MeSH Supplementary Concept]
- UfSP1 protein, mouse [MeSH Supplementary Concept]
- UfSP2 protein, mouse [MeSH Supplementary Concept]
- Ulp1 protease [MeSH Supplementary Concept]
- V-CATH protein, autographa californica nucleopolyhedrovirus [MeSH Supplementary Concept]
- VSCYSPR1 protein, vicia sativa [MeSH Supplementary Concept]
- VSCYSPR2 protein, vicia sativa [MeSH Supplementary Concept]
- War5.2 protein, triticum aestivum [MeSH Supplementary Concept]
- XCL-2 calpain [MeSH Supplementary Concept]
- acid cysteine proteinase, bombyx [MeSH Supplementary Concept]
- aleurain [MeSH Supplementary Concept]
- alg13 protein, zebrafish [MeSH Supplementary Concept]
- alkaline peptidase [MeSH Supplementary Concept]
- amebapain [MeSH Supplementary Concept]
- amoebapain protein, entamoeba histolytica [MeSH Supplementary Concept]
- angiotensin II degradation factor [MeSH Supplementary Concept]
- arginyllysine esteropeptidase [MeSH Supplementary Concept]
- artemia cathepsin L-like protease [MeSH Supplementary Concept]
- artemia trypsin-like proteinase [MeSH Supplementary Concept]
- asparaginyl endopeptidase, lysosomal [MeSH Supplementary Concept]
- avian adenovirus type 1 proteinase [MeSH Supplementary Concept]
- bradykinin hydrolyzing enzyme, epidermal [MeSH Supplementary Concept]
- bromelain protease F9 [MeSH Supplementary Concept]
- calcium dependent sulfhydryl protease [MeSH Supplementary Concept]
- calcium-dependent protease I [MeSH Supplementary Concept]
- calotropain-FI [MeSH Supplementary Concept]
- calotropain-FII [MeSH Supplementary Concept]
- calotropin DI [MeSH Supplementary Concept]
- calotropin DII [MeSH Supplementary Concept]
- calpain [MeSH Descriptor]
- calpain 10 [MeSH Supplementary Concept]
- calpain 5, rat [MeSH Supplementary Concept]
- calpain A, drosophila [MeSH Supplementary Concept]
- calpain Lp82 [MeSH Supplementary Concept]
- calpain p94 [MeSH Supplementary Concept]
- carica candamarencis glycosylated cysteine proteinase [MeSH Supplementary Concept]
- caricain II [MeSH Supplementary Concept]
- caspa protein, zebrafish [MeSH Supplementary Concept]
- caspase 10 [MeSH Descriptor]
- caspase 12 [MeSH Descriptor]
- caspase 14 [MeSH Descriptor]
- caspase 2 [MeSH Descriptor]
- caspase 3 [MeSH Descriptor]
- caspase 32, rat [MeSH Supplementary Concept]
- caspase 6 [MeSH Descriptor]
- caspase 7 [HGNC gene]
- caspase 8 [MeSH Descriptor]
- caspase 9 [MeSH Descriptor]
- caspases [MeSH Descriptor]
- caspases, effector [MeSH Descriptor]
- caspases, initiator [MeSH Descriptor]
- cat-L1B protein, fasciola gigantica [MeSH Supplementary Concept]
- cathepsin J [MeSH Supplementary Concept]
- cathepsin L1, fasciola hepatica [MeSH Supplementary Concept]
- cathepsin L5 [MeSH Supplementary Concept]
- cathepsin N [MeSH Supplementary Concept]
- cathepsin Q [MeSH Supplementary Concept]
- cathepsin W [MeSH Descriptor]
- cathepsin Y [MeSH Supplementary Concept]
- cathepsin-6 [MeSH Supplementary Concept]
- ced-3 protein, C elegans [MeSH Supplementary Concept]
- citvac enzyme [MeSH Supplementary Concept]
- comosain [MeSH Supplementary Concept]
- congopain [MeSH Supplementary Concept]
- cprG protein, dictyostelium [MeSH Supplementary Concept]
- cruzain, trypanosoma cruzi [MeSH Supplementary Concept]
- cruzipain [MeSH Supplementary Concept]
- csp-1 protein, C elegans [MeSH Supplementary Concept]
- csp-3 protein, C elegans [MeSH Supplementary Concept]
- ctsla protein, zebrafish [MeSH Supplementary Concept]
- ctsw protein, mouse [MeSH Supplementary Concept]
- ctsw protein, rat [MeSH Supplementary Concept]
- cysteine endopeptidase, xenopus skin [MeSH Supplementary Concept]
- cysteine endopeptidases [MeSH Descriptor]
- cysteine protease 2, giardia lamblia [MeSH Supplementary Concept]
- cysteine proteinase I [MeSH Supplementary Concept]
- cysteine proteinase-1, drosophila [MeSH Supplementary Concept]
- decay protein, drosophila [MeSH Supplementary Concept]
- dermatophagoides farinae antigen f 1 [MeSH Supplementary Concept]
- dermatophagoides pteronyssinus antigen p 1 [MeSH Supplementary Concept]
- drICE protein, Drosophila [MeSH Supplementary Concept]
- dredd protein, drosophila [MeSH Supplementary Concept]
- dronc protein, Drosophila [MeSH Supplementary Concept]
- dynorphin A-converting enzyme [MeSH Supplementary Concept]
- dynorphin converting enzyme [MeSH Supplementary Concept]
- endopeptidase B [MeSH Supplementary Concept]
- ervatamin [MeSH Supplementary Concept]
- ervatamin B [MeSH Supplementary Concept]
- ervatamin C, ervatamia coronaria [MeSH Supplementary Concept]
- falcipain [MeSH Supplementary Concept]
- falcipain 2 [MeSH Supplementary Concept]
- falcipain 3 [MeSH Supplementary Concept]
- fastuosain, bromelia fastuosa [MeSH Supplementary Concept]
- fce-1 protein, C elegans [MeSH Supplementary Concept]
- fce-2 protein, C elegans [MeSH Supplementary Concept]
- gingivain [MeSH Supplementary Concept]
- hemisphaericin [MeSH Supplementary Concept]
- hieronymain I, bromelia hieronymi [MeSH Supplementary Concept]
- hypertrophic cardiomyopathy 1 [DO Concept]
- interleukin 1beta-converting enzyme 2 [MeSH Supplementary Concept]
- karatasin [MeSH Supplementary Concept]
- m-calpain [MeSH Supplementary Concept]
- m-calpain proenzyme [MeSH Supplementary Concept]
- macrodontain II protein, pseudananas macrodontes [MeSH Supplementary Concept]
- macrodontain-I protein, pseudananas macrodontes [MeSH Supplementary Concept]
- melain [MeSH Supplementary Concept]
- mepS protein, E coli [MeSH Supplementary Concept]
- metacaspase 9, arabidopsis [MeSH Supplementary Concept]
- metacaspase-8, arabidopsis [MeSH Supplementary Concept]
- miltpain [MeSH Supplementary Concept]
- morrenain b I, morrenia brachystephana [MeSH Supplementary Concept]
- morrenain b II [MeSH Supplementary Concept]
- morrenain o II protein, morrenia odorata [MeSH Supplementary Concept]
- mu-calpain [MeSH Supplementary Concept]
- mu-calpain proenzyme [MeSH Supplementary Concept]
- myosin heavy chain 7 [ORDO Gene]
- neutral proteinase Pf105, plasmodium falciparum [MeSH Supplementary Concept]
- nsP2 proteinase [MeSH Supplementary Concept]
- nucellain protein, hordeum vulgare [MeSH Supplementary Concept]
- onchocerca volvulus L3 cysteine protease [MeSH Supplementary Concept]
- otub-1 protein, C elegans [MeSH Supplementary Concept]
- periodontain [MeSH Supplementary Concept]
- phytolacain G [MeSH Supplementary Concept]
- phytolacain R [MeSH Supplementary Concept]
- porphypain protein, porphyromonas gingivalis [MeSH Supplementary Concept]
- preprocathepsin B [MeSH Supplementary Concept]
- preprocathepsin C [MeSH Supplementary Concept]
- preprocathepsin H [MeSH Supplementary Concept]
- preprocathepsin L [MeSH Supplementary Concept]
- proaleurain [MeSH Supplementary Concept]
- procalpain [MeSH Supplementary Concept]
- procaricain [MeSH Supplementary Concept]
- procathepsin B [MeSH Supplementary Concept]
- procathepsin K [MeSH Supplementary Concept]
- procathepsin L [MeSH Supplementary Concept]
- procerain [MeSH Supplementary Concept]
- processing enzyme 1, vigna mungo [MeSH Supplementary Concept]
- proendoproteinase B [MeSH Supplementary Concept]
- prohormone thiol protease [MeSH Supplementary Concept]
- propapain [MeSH Supplementary Concept]
- prorenin processing enzyme [MeSH Supplementary Concept]
- protease p29 [MeSH Supplementary Concept]
- proteasome subunit Z [MeSH Supplementary Concept]
- proteinase I, dictyostelium discoideum [MeSH Supplementary Concept]
- proteinase yscD [MeSH Supplementary Concept]
- proteinase yscE [MeSH Supplementary Concept]
- prtR protein, porphyromonas gingivalis W50 [MeSH Supplementary Concept]
- prtT protein, porphyromonas gingivalis [MeSH Supplementary Concept]
- pseudotzain protein, pseudotsuga [MeSH Supplementary Concept]
- rhodesain [MeSH Supplementary Concept]
- seed-type vacuolar processing enzyme delta, arabidopsis [MeSH Supplementary Concept]
- soybean protease C2 [MeSH Supplementary Concept]
- staphopain A protein, staphylococcus aureus [MeSH Supplementary Concept]
- staphopain B protein, staphylococcus aureus [MeSH Supplementary Concept]
- succinyl-S-thiomethy-papain [MeSH Supplementary Concept]
- taspase1, drosophila [MeSH Supplementary Concept]
- taspase1, human [MeSH Supplementary Concept]
- taspase1, mouse [MeSH Supplementary Concept]
- tc 120 proteinase [MeSH Supplementary Concept]
- tccb protein, trypanosoma cruzi [MeSH Supplementary Concept]
- tetrain [MeSH Supplementary Concept]
- thaumatopain [MeSH Supplementary Concept]
- toxopain-1, toxoplasma gondii [MeSH Supplementary Concept]
- trypanopain tb [MeSH Supplementary Concept]
- vacuolar processing enzyme [MeSH Supplementary Concept]
- vacuolar processing enzyme alpha, arabidopsis [MeSH Supplementary Concept]
- vacuolar processing enzyme beta, arabidopsis [MeSH Supplementary Concept]
- vacuolar processing enzyme gamma, arabidopsis [MeSH Supplementary Concept]
- vetch protease B [MeSH Supplementary Concept]
- vignain [MeSH Supplementary Concept]
- vinckepain 2, plasmodium falciparum [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- caspase 7 [MeSH Descriptor]
- caspase 7 [MeSH concept]
OMIM relation
- Caspase 7, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CASP7 protein, human [MeSH Supplementary Concept]
- CASP7 protein, human [MeSH concept]
- caspase 7 [MeSH Descriptor]
- caspase 7 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP7 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Apoptotic DNA Fragmentation Pathway [NCIt concept]
- B-Cell Survival Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

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