Fas Signaling Pathway BioCarta

Preferred Label : Fas Signaling Pathway BioCarta;

NCIt synonyms : Fas Signaling Pathway;

NCIt related terms : FAS signaling pathway ( CD95 );

Alternative definition : BIOCARTA: Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligomerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated and then cleave and activate downstream caspases, and a variety of cellular substrates, leading to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure. They also cleave DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of Fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of Fas-mediated apoptosis. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_fasPathway;

Details

Origin ID

C39077;

UMLS CUI

C1517135;

Automatic exact mappings (from CISMeF team)
- Fas signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- CASP8 and FADD-Like Apoptosis Regulator [NCIt concept]
- Caspase-10 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Cholecystokinin [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Lamin-A/C [NCIt concept]
- Lamin-B1 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Prolyl Endopeptidase FAP [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 13 [NCIt concept]
pathway_has_gene_element
- CASP10 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CCK wt Allele [NCIt concept]
- CFLAR wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- FAP wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LMNA wt Allele [NCIt concept]
- LMNB1 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- PTPN13 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RIPK2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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