Caspase-6 - CISMeF

Preferred Label : Caspase-6;

NCIt synonyms : Apoptotic Protease Mch-2; CASP6 Protein; CASPASE 6, Apoptosis-Related Cysteine Protease; CASP6; MCH2; Apoptotic Cysteine Protease MCH2; EC 3.4.22.59;

NCIt definition : Caspase-6 (293 aa, 33 kDa) is encoded by the human CASP6 gene. This protein plays a role in caspase activation and apoptosis.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.;

Details

Origin ID

C28436;

UMLS CUI

C1448894;

Currated CISMeF NLP mapping
- caspase 6 [MeSH Descriptor]
- caspase 6 [MeSH concept]
OMIM relation
- Caspase 6, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CASP6 protein, human [MeSH Supplementary Concept]
- CASP6 protein, human [MeSH concept]
- caspase 6 [MeSH concept]
- caspase 6 [MeSH Descriptor]
gene_encodes_gene_product
- CASP6 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- West Nile Virus Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients