CASP6 wt Allele

Preferred Label : CASP6 wt Allele;

NCIt synonyms : CASPASE 6, Apoptosis-Related Cysteine Protease wt Allele; MCH2; Apoptotic Cysteine Protease MCH2 Gene; Apoptotic Protease MCH-2 Gene; Caspase 6 Gene; Caspase-6 Gene;

NCIt definition : Human CASP6 wild-type allele is located within 4q25 and is approximately 15 kb in length. This allele, which encodes caspase-6 protein, plays a role in the cleavage and activation of both lamins and poly (ADP-ribose) polymerase (PARP) during apoptosis. Overexpression of the CASP6 gene promotes programmed cell death.;

GenBank Accession Number : NM_001226;

Details

Origin ID

C49557;

UMLS CUI

C1705064;

OMIM relation
- Caspase 6, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 4: 110982233-110967389 [NCIt concept]
gene_in_chromosomal_location
- 4q25 [NCIt concept]
gene_is_element_in_pathway
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- West Nile Virus Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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