HIV-I Nef in Apoptosis Pathway

Preferred Label : HIV-I Nef in Apoptosis Pathway;

NCIt related terms : HIV-I Nef: negative effector of Fas and TNF;

Alternative definition : BIOCARTA: HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be induced through the expression of Fas ligand on the surface of HIV-infected cells, stimulating the Fas-dependent apoptotic pathway in cells that come in contact with infected cells. The NEF protein expressed by HIV may play a role in the inducing the expression of Fas-ligand by infected cells. If this is the case, then a question that arises is how infected cells themselves escape Fas-mediated apoptosis. The NEF protein appears to play a role in this process as well. NEF interacts with the ASK1 kinase (apoptosis signal-regulating kinase) involved in apoptotic signaling by TNF and Fas-ligand. Interaction of NEF with ASK1 prevents phosphorylation of downstream MAP kinases and JNK kinases involved in apoptotic signaling. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_HivnefPathway;

Details

Origin ID

C39106;

UMLS CUI

C1512300;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Actin, Cytoplasmic 2 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BAG Family Molecular Chaperone Regulator 4 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- CASP8 and FADD-Like Apoptosis Regulator [NCIt concept]
- Caspase-2 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cyclin-Dependent Kinase 11B [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Gelsolin [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Lamin-A/C [NCIt concept]
- Lamin-B1 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 5 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Nuclear Mitotic Apparatus Protein 1 [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- TNF Receptor-Associated Factor 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- ACTG1 wt Allele [NCIt concept]
- APAF1 wt Allele [NCIt concept]
- BAG4 wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- BIRC3 wt Allele [NCIt concept]
- CASP2 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CDK11B wt Allele [NCIt concept]
- CFLAR wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- GSN wt Allele [NCIt concept]
- LMNA wt Allele [NCIt concept]
- LMNB1 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP3K5 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NUMA1 wt Allele [NCIt concept]
- PRKCD wt Allele [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF1 wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]

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