Mitogen-Activated Protein Kinase Kinase Kinase 5

Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase 5;

NCIt synonyms : MAPK/ERK Kinase Kinase 5; Apoptosis Signal-Regulating Kinase 1; EC 2.7.11.25; MAP/ERK Kinase Kinase 5; MEK Kinase 5; Apoptosis Signal Regulating Kinase 1; ASK1; MAP3K5;

NCIt definition : Mitogen-activated protein kinase kinase kinase 5 (1374 aa, 155 kDa) is encoded by the human MAP3K5 gene. This protein is involved in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.;

Details

Origin ID

C106623;

UMLS CUI

C1436155;

Automatic exact mappings (from CISMeF team)
- MAP kinase kinase kinase 5 [MeSH Descriptor]
- Mitogen-activated protein kinase kinase kinase 5 [OMIM gene]
- mitogen-activated protein kinase kinase kinase 5 [HGNC gene]
OMIM relation
- Mitogen-activated protein kinase kinase kinase 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP3K5 protein, human [MeSH Supplementary Concept]
- MAP3K5 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP3K5 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Selonsertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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