" /> Apoptosis Regulator Bcl-2 - CISMeF





Preferred Label : Apoptosis Regulator Bcl-2;

NCIt synonyms : BCL-2 Protein; B-Cell CLL/lymphoma 2; B-Cell CLL Lymphoma-2;

NCIt related terms : BCL2; B-cell leukemia/lymphoma 2 protein;

NCIt definition : Apoptosis regulator Bcl-2 (239 aa, 26 kDa) is encoded by the human BCL2 gene. This protein plays a role in cellular survival.;

Alternative definition : NCI-GLOSS: A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying.;

NCIt note : A mitochondrial membrane protein, BCL-2 protein is responsible for blocking apoptosis in normal cells. Growth factor-stimulated phosphorylation by PKC promotes anti-apoptotic activity of BCL-2 during G2/M. BCL-2 regulates cell death by controlling mitochondrial membrane permeability. Cleavage by caspases during apoptosis yields a pro-apoptotic BCL-2 product that causes release of cytochrome C into the cytosol, promoting further caspase activity. Over expression from translocation t(14;18) of BCL-2 with the immunoglobulin gene region is involved in B-cell lymphomas. (from OMIM 151430 and NCI);

Codes from synonyms : CDR0000613897; CDR0000613899;

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18/05/2024


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