Preferred Label : Bcl-2 Inhibitor ZN-d5;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
Bcl-2 inhibitor ZN-d5 targets, binds to and inhibits the activity of Bcl-2. This restores
apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays
an important role in the negative regulation of apoptosis; its expression is associated
with increased drug resistance and tumor cell survival.;
Molecule name : ZN d5; ZN-d5;
NCI Metathesaurus CUI : CL1647808;
Origin ID : C178326;
UMLS CUI : C5554951;
Semantic type(s)
- concept_is_in_subset
- has_target
